Arvind K. Badhey, Julia S. Schwarz, Benjamin M. Laitman, Brandon M. Veremis, William H. Westra, Mike Yao, Marita S. Teng, Eric M. Genden, Brett A. Miles; JAMA Otolaryngology-Head & Neck Surgery, Dec. 1, 2022
This study evaluated the feasibility of using WF-OCT for visualizing microstructures at the margins of excised oral cavity and oropharyngeal tissue. The findings suggest that WF-OCT may be a promising imaging modality for intraoperative analysis in head and neck surgery, especially at deep margins, without impacting specimen integrity or surgical and pathology workflows.
Beth B. DuPree, Michael J. Papez, Elaina Pirruccello, Audrey Hassenﬂug; Indian Journal of Surgery, Nov. 26, 2021; Association of Surgeons of India 2021
This paper reports on the intraoperative use of Optical Coherence Tomography (OCT) in 3 patients with DCIS. In all 3 cases, additional lesions identiﬁed by OCT during surgery were also noted in histopathology reports 3 to 5 days post-surgery, suggesting that intraoperative use of OCT is a valuable tool for margin determination in real-time.
Hank Schmidt, Courtney Connolly, Shabnam Jaﬀer, Twisha Oza, Christina R Weltz, Elisa R Port, Adriana Corben; The Breast Journal, Oct. 14, 2019
In this pilot study, evaluation of wide-ﬁeld Optical Coherence Tomography demonstrated concordance with histology at tissue margins, supporting its potential for use as a real-time adjunct intraoperative imaging tool for margin assessment in surgically excised breast tissue.
Richard Ha, MD; Lauren C. Friedlander, MD; Hanina Hibshoosh, MD; Christine Hendon, PhD; Sheldon Feldman, MD; Soojin Ahn, MD; Hank Schmidt, MD, PhD; Margaret K. Akens, PhD; MaryAnn Fitzmaurice, MD, PhD; Brian C. Wilson, PhD; Victoria L. Mango, MD; Academic Radiology, Nov. 22, 2017
Study results display the potential for Optical Coherence Tomography (OTC) as a real-time intraoperative tool for post-lumpectomy specimen margin assessment. This study revealed a relatively short training time and showed that readers from diﬀerent medical specialties were able to distinguish suspicious from non-suspicious OCT imaging ﬁndings in ex vivo breast tissue conﬁrmed by histology.
Lee Wilke, Adriana Corben, Elisa Port, Christina Weltz2, J. Jamie Alberty-Oller, Kaelin Grant, Mitch Piel, Hank Schmidt; ASBrS, Oﬃcial Proceedings, Volume XXI, PAGE 187, 2020 Virtual Scientiﬁc Session
This abstract presents the eﬀectiveness of lumpectomy specimen stabilization with a compression bag using Perimeter’s OTIS™ Optical Coherence Tomography (OTC) device. The use of compression to improve lumpectomy specimen imaging did not compromise specimen integrity for pathology and showed no statistical diﬀerence in re-excision rates. The OTIS™ OCT device seamlessly integrated into the intraoperative workﬂow for breast specimen imaging.