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Perimeter is conducting a randomized, controlled, multi-site, pivotal study to test its B-Series OCT2 with ImgAssist AI against the current standard of care and assess the impact on re-operation rates for patients undergoing breast conservation surgery. This project is made possible, in part, by a $7.4 million grant awarded by the Cancer Prevention and Research Institute of Texas (CPRIT), a leading state body that funds cancer research.

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Potential Utility of Adjunct Imaging with Wide-Field Optical Coherence Tomography for Gross and Microscopic Evaluation of Breast Specimens in Real-Time in the Operating Suite

Beth B. DuPree, Michael J. Papez, Elaina Pirruccello, Audrey Hassenflug; Indian Journal of Surgery, Nov. 26, 2021; Association of Surgeons of India 2021

This paper reports on the intraoperative use of Optical Coherence Tomography (OCT) in 3 patients with DCIS. In all 3 cases, additional lesions identified by OCT during surgery were also noted in histopathology reports 3 to 5 days post-surgery, suggesting that intraoperative use of OCT is a valuable tool for margin determination in real-time.

Evaluation of surgically excised breast tissue microstructure using wide-field Optical Coherence Tomography

Hank Schmidt, Courtney Connolly, Shabnam Jaffer, Twisha Oza, Christina R Weltz, Elisa R Port, Adriana Corben; The Breast Journal, Oct. 14, 2019

In this pilot study, evaluation of wide-field Optical Coherence Tomography demonstrated concordance with histology at tissue margins, supporting its potential for use as a real-time adjunct intraoperative imaging tool for margin assessment in surgically excised breast tissue.

Optical Coherence Tomography: A Novel Imaging Method for Post-lumpectomy Breast Margin Assessment —A Multi-reader Study

Richard Ha, MD; Lauren C. Friedlander, MD; Hanina Hibshoosh, MD; Christine Hendon, PhD; Sheldon Feldman, MD; Soojin Ahn, MD; Hank Schmidt, MD, PhD; Margaret K. Akens, PhD; MaryAnn Fitzmaurice, MD, PhD; Brian C. Wilson, PhD; Victoria L. Mango, MD; Academic Radiology, Nov. 22, 2017

Study results display the potential for Optical Coherence Tomography (OTC) as a real-time intraoperative tool for post-lumpectomy specimen margin assessment. This study revealed a relatively short training time and showed that readers from different medical specialties were able to distinguish suspicious from non-suspicious OCT imaging findings in ex vivo breast tissue confirmed by histology.

Feasibility Study of the Intra-operative Use of the OTIS™, Wide Field Optical Coherence Tomography (WF-OCT) in Surgically Excised Partial-mastectomy Breast Tissue

Lee Wilke, Adriana Corben, Elisa Port, Christina Weltz2, J. Jamie Alberty-Oller, Kaelin Grant, Mitch Piel, Hank Schmidt; ASBrS, Official Proceedings, Volume XXI, PAGE 187, 2020 Virtual Scientific Session

This abstract presents the effectiveness of lumpectomy specimen stabilization with a compression bag using Perimeter’s OTIS™ Optical Coherence Tomography (OTC) device. The use of compression to improve lumpectomy specimen imaging did not compromise specimen integrity for pathology and showed no statistical difference in re-excision rates. The OTIS™ OCT device seamlessly integrated into the intraoperative workflow for breast specimen imaging.

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Perimeter is fully committed to helping surgeons and clinicians achieve a high level of expertise, efficiency and confidence as they adopt our technology in their OR.

Meet the Team


Patient Story
Mary Leas discusses her breast cancer diagnosis and involvement in a clinical trial using Perimeter’s technology.
Webcast Replay
Jeremy Sobotta, CEO, provides a corporate update on Perimeter's progress toward achieving key objectives, as well as commercial, clinical and product development milestones.
Case Study
Breast cancer surgeon, Dr. Beth DuPree, explains the benefits of using Perimeter's S-Series OCT technology in the OR.

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